产品货号：
Z31594
中文名称：
DNA Polymerase Beta/POLB抗体
英文名称：
Anti-DNA Polymerase Beta/POLB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DNA Polymerase Beta/POLB Antibody |
| 指标别名 | DNA polymerase beta;POLB |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,IP |
| 基因名称 | POLB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human DNA Polymerase beta Repair polymerase.Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. |
| 实际分子量 | 38KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Polymerase (DNA directed),beta,also known as POLB,is an enzyme that,in humans,is encoded by the POLB gene.It is localized on 8p11.2.The protein encoded by this gene is a DNA polymerase involved in base excision and repair,also called gap-filling DNA synthesis.It is found that a truncated POLB is expressed in primary colorectal tumors and inhibits the normal repair function of wildtype POLB.The encoded protein,acting as a monomer,is normally found in the cytoplasm,but it translocates to the nucleus upon DNA damage.Several transcript variants of this gene exist,but the full-length nature of only one has been described to date.Additionally,human POLB forms a complex with and is methylated by PRMT6.In vitro,methylated POLB possesses significantly higher DNA polymerase activity when compared to that of unmodified enzyme.The increase in DNA polymerase activity upon methylation is due to the enhanced DNA binding and processivity of POLB. |
| Uniprot ID | P06746 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 |
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