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产品目录

DNA Polymerase Beta/POLB抗体图片
产品货号:
Z31594
中文名称:
DNA Polymerase Beta/POLB抗体
英文名称:
Anti-DNA Polymerase Beta/POLB Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-DNA Polymerase Beta/POLB Antibody
指标别名DNA polymerase beta;POLB
克隆性Monoclonal
检验物种human,mouse,rat
应用范围WB,IHC,ICC/IF,IP
基因名称POLB
抗体来源Rabbit
抗体类型IgG
免疫原A synthesized peptide derived from human DNA Polymerase beta Repair polymerase.Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
实际分子量38KD
成分500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol.
纯化方式Affinity-chromatography
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Polymerase (DNA directed),beta,also known as POLB,is an enzyme that,in humans,is encoded by the POLB gene.It is localized on 8p11.2.The protein encoded by this gene is a DNA polymerase involved in base excision and repair,also called gap-filling DNA synthesis.It is found that a truncated POLB is expressed in primary colorectal tumors and inhibits the normal repair function of wildtype POLB.The encoded protein,acting as a monomer,is normally found in the cytoplasm,but it translocates to the nucleus upon DNA damage.Several transcript variants of this gene exist,but the full-length nature of only one has been described to date.Additionally,human POLB forms a complex with and is methylated by PRMT6.In vitro,methylated POLB possesses significantly higher DNA polymerase activity when compared to that of unmodified enzyme.The increase in DNA polymerase activity upon methylation is due to the enhanced DNA binding and processivity of POLB.
Uniprot IDP06746
推荐稀释比
Western blot (WB) 1:500~2000
Immunohistochemistry in paraffin section (IHC) 1:20~100
Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20~100
Immunocoprecipitation 1:20

相关搜索:DNA Polymerase Beta/POLB抗体DNA Polymerase Beta抗体POLB单抗Anti-DNA Polymerase Beta/POLB Antibody
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